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Cake day: August 20th, 2023

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  • I agree it may have presented barriers for coordination the FDA and access to US markets. I haven’t been able to dig deep into the Cuban studies, but just because something is labeled a phase 3 or phase 4 by the investigators doesn’t necessarily mean it was done to the standards necessary for fda approval or in the correct context of current standard of care treatments in the US or who knows how many other issues. If it was fully ready for all markets as is and required no further investigations, and it was only the US FDA causing problems, I would expect it to have already been widely available in many other countries that don’t have embargos with Cuba, like all of Europe. Currently it’s only available in Cuba, Colombia, Bosnia and Herzegovina, Peru, and Paraguay.

    Mostly though I didn’t want someone to accidentally misread this and think it meant cure. I realize you did not say that, but it’s just a common misreading I’ve noticed people make of the term cancer vaccines when they’ve been mentioned in popular media. Didn’t want someone to drag their poor dying relative off to Paraguay thinking they’re getting cured.

    I agree the Cuban embargo is ridiculous, should be stopped, and is hurting both countries with no benefit to anyone (other than keeping a certain segment of voters in Florida happy).


  • It’s also not a vaccine in the sense it’s preventing cancer, it’s for the treatment of cancer that is already there, specifically non small cell lung cancers (though it’s being tested in other cancers that use the signaling mechanism being targeted). Not saying it’s impossible that it could prevent cancer, just that it hasn’t been tested in that way to the best of my knowledge.

    There is some precedence for a vaccine like that though. The HPV vaccine for instance prevents HPV (and therefore hpv related cancers), but is also used as a treatment if an HPV related cancer develops.


  • Slight correction on that vaccine, the FDA doesn’t authorize any drug for sale in the US that hasn’t passed it’s rigorous trials and gone through its approval process. It’s currently being tested and has more trials ongoing right now. FDA will be able to approve it for sale if it passes its trials.

    https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.9135

    Also the word cancer vaccine kind of implies cure to some, but it’s not by any means:

    “MST was 10.83 months for vaccinated vs. 8.86 months for non-vaccinated. In the Phase III trial, the 5-year survival rate was 14.4% for vaccinated subjects vs. 7.9% for controls.”

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346887/

    So it might be a useful tool but just don’t want to get hopes up unnecessarily. People who’s immune system reacted to the vaccine the strongest did best, so current trials are focused on combining it with an immune checkpoint inhibitor drug to increase the immune response even more hopefully (and those drugs are already being used by themselves in cancer). These drugs block “checkpoints” in the immune system that would normally stop it from attacking things like yourself, which we kind of want it to do in cancer.

    Not saying I support an embargo in Cuba, I don’t, just don’t want this comment to be inadvertently read as “Cuba has had the cure to lung cancer this whole time and you’re not allowed to have it!” which isn’t true.



  • Yes not disputing at all that there’s a proxy war (though Soviet Israeli relationship deteriorated long before that started with Soviets funding Israeli opponents since 1967), just that despite or partially because of this, Israel is closer to Russia than most western countries. Isreal doesn’t want to upset Russia and give them more incentive to fund proxies against them, and some Israeli governments, like Netanyahu’s especially, have helped provide cover for Russian actions. And Russia at times will often take surprisingly pro Israeli moves despite also funding proxies.

    I don’t think it would be impossible for Israel to switch alignment to Russia, and I think you would quickly see Russia providing cover and stopping any assistance with proxy conflict against them. It would be essentially accomplishing Russia’s goal, so what would they have to fight Israel about anymore? Putin is a real politic great powers kind of leader who has no qualms about butchering civilians by the thousands. He’s certainly not aligned with Iran because he’s concerned about Palestinians. Israel becoming fully aligned with Russia would be accomplishing a 77 year in the making goal for the Soviet Union and Russia.


  • That’s true, but also a little more complicated than that I think. At least one of the reasons Israel was able to extract so much aid from the US to begin with was the threat they could align with the Soviet Union (initially one of the biggest supporters of Israel, and first to recognize them as a state officially in 1947, though they had a few others had unofficially recognized them by then). Stalin had a zionist foreign policy, despite (or maybe because of) being antisemitic himself. Though Soviets and Israel largely schismed in 1967 and the Soviet union began throwing its funding behind the surrounding Arab states.

    Relations warmed in the 90s again but have been up and down since. But there has been a lot of Russian immigration to Isreal. Russian is the third most spoken language in Israel.

    2011, Putin said: “Israel is, in fact, a special state to us. It is practically a Russian-speaking country. Israel is one of the few foreign countries that can be called Russian-speaking. It’s apparent that more than half of the population speaks Russian”.[38] Putin additionally claimed that Israel could be considered part of the Russian cultural world, and contended that “songs which are considered to be national Israeli songs in Israel are in fact Russian national songs”. He further stated that he regarded Russian-speaking Israeli citizens as his compatriots and part of the ‘Russian World’

    Israel at times has been quite friendly to Russia. It took a neutral stance on the Crimea annexation, infuriating the United States. Russia recognized Jerusalem as the capital of Israel in 2017. Israel refused to recognize Russians assassinating people abroad, infuriating the UK. Netanyahu has spoke often about his friendship with Putin. Israel refused to impose sanctions on Russia or send defensive weapons to Ukraine.

    I mean you could go on, it’s a complicated relationship, with especially Netanyahu favoring closer relations with Russia and trying to play both sides. Iran’s relationship with Russia certainly presents complications, but I don’t think Israel getting closer to Russia or at least using the threat of it to extract more from the United States is out of the question. They’re often trying to “play both sides” of the Russia and US divide to their benefit. Especially if Netanyahu remains in power.

    https://www.axios.com/2022/10/25/ukraine-russia-israel-netanyahu-putin-lapid-kuleba

    https://www.washingtoninstitute.org/policy-analysis/netanyahu-governments-approach-russia-and-ukraine

    https://en.m.wikipedia.org/wiki/Israel–Russia_relations

    China and Israel have had surprisingly good relations too. And again, Netanyahu has consistently tried to make those closer, possibly to help keep US aid flowing.

    https://www.timesofisrael.com/with-israeli-us-ties-troubled-china-says-xi-looking-forward-to-netanyahu-visit/

    Not saying the US shouldn’t cut off Isreal, please do, but the results may be surprising if that were to actually happen. I don’t think putin harbors any particular concerns for the plight of the Palestinian people.



  • I’m not sure what you mean? This article is about AMD. Nvidia is the one that skimps on the vram. Amd’s 7800 xt has 16 gb of vram and is $500. Their most expensive gpu is the 7900 xtx for about $950 currently and it has 24 gb.

    Nvidia 4080 is over $1000 and has 16 gb of vram though.

    I agree gpus are too expensive, but if amd gpus go under, Nvidia will have even more power to price gouge. I’m rooting for Intel too to bring even more competition in.


  • Edit: sorry I think my first answer posted earlier was wrong, after more review I misunderstood “audit percentage,” it would be the percentage of taxpayers in those brackets who get audited, not the percentage of audits that bracket makes up of all audits. Below answer should be closer now.

    If you’re curious you can use the percentage from article and do simple math to find the number.

    Those making more than $10 million will go from 11% of them being audited to 16.5%. And we can get data on tax return audit actual numbers below.

    https://www.irs.gov/statistics/compliance-presence

    So diving back to the numbers, there were 3,353 audits of individuals make $10 million or more in 2023, meaning if the audit rate was 11% there were would be about 30,481 individuals total in this bracket that filed that year. So the higher audit rate would bring it to a total of about 5,029 audits of those making ten million or more, assuming the number of audits and number of people filing in that bracket are constant.

    Also here are the audit rates by tax bracket for 2022 and 2021.

    https://www.irs.gov/pub/irs-utl/statement-for-updated-audit-rates-ty-19.pdf

    The $10 million plus bracket went from only 2% audited in 2021 to 8% audited in 2022. Wonder what changed between those years…


  • First of all, it’s not like Biden sat down and wrote these himself. Appointees by Biden at the health and human service administration directed these rules be written by civil servants who work at the department. Changes to regulations have to follow the processes laid out in the laws originally passed by congress giving the agency the authority to write that regulation. Usually that involves a long process of research, mandatory waiting periods, comments, legal reviews, votes by administrators, etc. These new rules began to be drafted in January 2022. Here’s all about 600 pages of them. It’s not something like, Biden rolled out of bed this morning and decided to reverse lgbtq discrimination in healthcare finally to help himself in the election. The rule this is replacing/updating for instance had work on it begin in 2015 that didn’t finish until 2020.

    If the complex processes for these new regulations aren’t followed then they aren’t drawing their power from any law, and they’ll be struck down by courts in a heartbeat. This happened to a lot of Trump’s incompetent administrators who had a lot of hastily passed or incorrectly passed regulations that didn’t survive legal review.

    https://www.vox.com/2021/1/19/22239074/affordable-clean-energy-rule-vacated-trump-court-climate-change-obama-biden




  • It’s just a multiple choice test with question prompts. This is the exact sort of thing an LLM should be very good at. This isn’t chat gpt trying to do the job of an actual doctor, it would be quite abysmal at that. And even this multiple choice test had to be stacked in favor of chat gpt.

    Because GPT models cannot interpret images, questions including imaging analysis, such as those related to ultrasound, electrocardiography, x-ray, magnetic resonance, computed tomography, and positron emission tomography/computed tomography imaging, were excluded.

    Don’t get me wrong though, I think there’s some interesting ways AI can provide some useful assistive tools in medicine, especially tasks involving integrating large amounts of data. I think the authors use some misleading language though, saying things like AI “are performing at the standard we require from physicians,” which would only be true if the job of a physician was filling out multiple choice tests.


  • Oh absolutely, agreed on all points. I was just saying there’s a possibility others beyond Medicare recipients might see some improvement in prices on these drugs as a result of this, but it doesn’t address the many many root problems with our current system like you say. Americans are still going to be massively overpaying on drugs. At least one small step in the right direction though, Medicare paying less for drugs benefits us all indirectly too some since everyone is paying into that with taxes.