Dementia, which includes Alzheimer's disease, currently affects around 1.8 million people in Germany. The exact cause has not yet been clarified, but genetic factors play a significant role in the development of the disease. Most previous analyses aimed at the identification of novel Alzheimer's genes used, a "case-control design."

Dementia, which includes Alzheimer’s disease, currently affects around 1.8 million people in Germany. The exact cause has not yet been clarified, but genetic factors play a significant role in the development of the disease. Most previous analyses aimed at the identification of novel Alzheimer’s genes used, a “case-control design.”